Detection and Metabolic Characterization in DOPA PET/CT of no Treated Brain Metastases of Lung Cancer, Breast Cancer and Melanoma

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

About 20 to 30% of patients treated for cancer will have brain metastases. These brain metastases are found more frequently in patients with lung cancer, breast cancer or melanoma. The prognosis of these patients is unfavorable but prolonged survival can be obtained with the local and systemic treatments currently available. Brain MRI is the gold standard for evaluating brain metastases but has limitations in therapeutic evaluation, partially offset by PET imaging of amino acid metabolism. Our work aims to compare the performance of PET-DOPA with standard MRI for the detection of brain metastases (≥ 5mm) in lung cancer, breast cancer and melanoma; and to characterize these lesions using dynamic acquisitions obtained with a digital PET camera with high spatial resolution. Having better knowledge of the metabolic characteristics of newly discovered brain metastases, the objective of subsequent studies will be to better assess the per- or post-therapeutic efficacy of radiotherapy and the various systemic therapies available (chemotherapy, targeted therapy, immunotherapy).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Primitive cancer (brest cancer, lung cancer, melanoma) proven histologically

• Presence of brain metastasis visualized on MRI, of which at least one measures 5 mm

• Age \> 18 years

• Patient has valid health insurance

• Written informed consent obtained from the patient prior to performing any protocol-related procedures, including screening evaluations

Locations
Other Locations
France
CHU Angers
RECRUITING
Angers
Institut de Cancerologie de l'Ouest
RECRUITING
Angers
Institut de Cancerologie de L'Ouest
RECRUITING
Saint-herblain
Contact Information
Primary
Oliver MOREL, MD
olivier.morel@ico.unicancer.fr
241352700
Time Frame
Start Date: 2021-12-03
Estimated Completion Date: 2026-02
Participants
Target number of participants: 52
Treatments
Experimental: F-DOPA PET/CT
Drug: 18 F-DOPA Radiation: F-DOPA PET CT
Related Therapeutic Areas
Sponsors
Leads: Institut Cancerologie de l'Ouest

This content was sourced from clinicaltrials.gov